Target
Alpha-1B adrenergic receptor
Ligand
BDBM50187749
Substrate
n/a
Meas. Tech.
ChEMBL_1513484 (CHEMBL3611840)
Ki
3.0±n/a nM
Citation
 Hayashi, ROhmori, EMoriwaki, MKumagai, HIsogaya, M Indolylpiperidine derivatives as potent and selectivea1B adrenoceptor antagonists. Bioorg Med Chem Lett 25:3921-3 (2015) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
56606.71
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortical membranes.
Residue:
515
Sequence:
MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
  
Inhibitor
Name:
BDBM50187749
Synonyms:
3-(1-(3-(piperidin-1-yl)propyl)piperidin-4-yl)-1H-indole dihydrochloride | CHEMBL537428
Type:
Small organic molecule
Emp. Form.:
C21H31N3
Mol. Mass.:
325.4909
SMILES:
C(CN1CCCCC1)CN1CCC(CC1)c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: