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TargetBeta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
LigandBDBM50117663
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1515027
IC50 6.0±n/a nM
Citation Huard, KLondregan, ATTesz, GBahnck, KBMagee, TVHepworth, DPolivkova, JCoffey, SBPabst, BAGosset, JRNigam, AKou, KSun, HLee, KHerr, MBoehm, MCarpino, PAGoodwin, BPerreault, CLi, QJorgensen, CCTkalcevic, GTSubashi, TAAhn, K Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. J Med Chem58:7164-72 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Name:Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms:GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Type:PROTEIN
Mol. Mass.:61324.81
Organism:Homo sapiens (Human)
Description:ChEMBL_107586
Residue:533
Sequence:
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQA
SPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKP
GTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGP
SCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCES
NFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDG
VSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLE
VVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCS
WCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEH
MYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50117663
NameBDBM50117663
Synonyms:CHEMBL3613707
TypeSmall organic molecule
Emp. Form.C25H22FN5O4S
Mol. Mass.507.537
SMILESCOc1cccc(CC(=O)N2Cc3ccc(cc3C2)S(=O)(=O)Nc2cnn(n2)-c2ccc(F)cc2)c1
Structure
n/a