Target
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Ligand
BDBM50117664
Substrate
n/a
Meas. Tech.
ChEMBL_1515027 (CHEMBL3616091)
IC50
631±n/a nM
Citation
 Huard, KLondregan, ATTesz, GBahnck, KBMagee, TVHepworth, DPolivkova, JCoffey, SBPabst, BAGosset, JRNigam, AKou, KSun, HLee, KHerr, MBoehm, MCarpino, PAGoodwin, BPerreault, CLi, QJorgensen, CCTkalcevic, GTSubashi, TAAhn, K Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3. J Med Chem 58:7164-72 (2015) [PubMed]  Article 
Target
Name:
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT3 | GNT-III | GlcNAc-T III | MGAT3 | MGAT3_HUMAN | N-acetylglucosaminyltransferase III | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III
Type:
PROTEIN
Mol. Mass.:
61324.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107586
Residue:
533
Sequence:
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLVSSFFWNNAPVTPQASPEPGGPDLLRTPLYSHSPLLQPLPPSKAAEELHRVDLVLPEDTTEYFVRTKAGGVCFKPGTKMLERPPPGRPEEKPEGANGSSARRPPRYLLSARERTGGRGARRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAINVNHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTVDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRGLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDRFHYLLDNPYQEPRSTAAGGWRHRGPEGRPPARGKLDEAEV
  
Inhibitor
Name:
BDBM50117664
Synonyms:
CHEMBL3613708
Type:
Small organic molecule
Emp. Form.:
C22H25N5O4S
Mol. Mass.:
455.53
SMILES:
COc1cccc(CC(=O)N2Cc3ccc(cc3C2)S(=O)(=O)Nc2cnn(n2)C(C)C)c1
Structure:
Search PDB for entries with ligand similarity: