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Target
Polymerase acidic protein
Ligand
BDBM50122445
Substrate
n/a
Meas. Tech.
ChEMBL_1519446 (CHEMBL3625380)
IC50
>500000±n/a nM
Citation
 Pala, N; Stevaert, A; Dallocchio, R; Dessė, A; Rogolino, D; Carcelli, M; Sanna, V; Sechi, M; Naesens, L Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors. ACS Med Chem Lett 6:866-71 (2015) [PubMed]  Article 
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_I000X | Polymerase acidic protein | RNA-directed RNA polymerase subunit P2
Type:
PROTEIN
Mol. Mass.:
82546.82
Organism:
Influenza A virus (strain A/X-31 H3N2)
Description:
ChEMBL_109885
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKTMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIIVELGDPSALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEITGTMRKLADQSLPPNFSSLENFRAYVDGFEPNGYIEGKLSQMSKEVNARIEPFLKTTPRPLRLPNGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPNVVKPHEKGINPNYLLSWKQVLAELQDIENEEKIPKTKNMKKTSQLKWALGENMAPEKVDFDDCKDVGDLKQYDSDEPELRSLASWIQNEFNKACELTDSSWIELDEIGEDVAPIEHIASMRRNYFTSEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLIRSAIGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEESSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLIVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALS
  
Inhibitor
Name:
BDBM50122445
Synonyms:
CHEMBL463072
Type:
Small organic molecule
Emp. Form.:
C14H15NO5
Mol. Mass.:
277.2726
SMILES:
CCOC(=O)c1c(O)c2cc(OC)ccc2n(C)c1=O
Structure:
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