Reaction Details Report a problem with these data
Target
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Ligand
BDBM50324539
Substrate
n/a
Meas. Tech.
ChEMBL_1523468 (CHEMBL3630812)
IC50
1000±n/a nM
Citation
Dounay, AB; Tuttle, JB; Verhoest, PR Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway. J Med Chem 58:8762-82 (2015) [PubMed] Article
More Info.:
Target
Name:
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:
AADAT_RAT | Aadat | Kat2 | Kynurenine/alpha-aminoadipate aminotransferase
Type:
PROTEIN
Mol. Mass.:
47788.12
Organism:
Rattus norvegicus
Description:
ChEMBL_826599
Residue:
425
Sequence:
MNYSRFLTATSLARKTSPIRATVEIMSRAPKDIISLAPGSPNPKVFPFKSAVFTVENGSTIRFEGEMFQRALQYSSSYGIPELLSWLKQLQIKLHNPPTVNYSPNEGQMDLCITSGCQDGLCKVFEMLINPGDTVLVNEPLYSGALFAMKPLGCNFISVPSDDCGIIPEGLKKVLSQWKPEDSKDPTKRTPKFLYTIPNGNNPTGNSLTGDRKKEIYELARKYDFLIIEDDPYYFLQFTKPWEPTFLSMDVDGRVIRADSLSKVISSGLRVGFITGPKSLIQRIVLHTQISSLHPCTLSQLMISELLYQWGEEGFLAHVDRAIDFYKNQRDFILAAADKWLRGLAEWHVPKAGMFLWIKVNGISDAKKLIEEKAIEREILLVPGNSFFVDNSAPSSFFRASFSQVTPAQMDLVFQRLAQLIKDVS
Inhibitor
Name:
BDBM50324539
Synonyms:
(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid | CHEMBL1215659
Type:
Small organic molecule
Emp. Form.:
C17H19FN4O4
Mol. Mass.:
362.3556
SMILES:
C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O |r|