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Target
Estradiol 17-beta-dehydrogenase 2
Ligand
BDBM50126973
Substrate
n/a
Meas. Tech.
ChEMBL_1524167 (CHEMBL3631252)
IC50
49±n/a nM
Citation
 Abdelsamie, AS; Bey, E; Gargano, EM; van Koppen, CJ; Empting, M; Frotscher, M Towards the evaluation in an animal disease model: Fluorinated 17ß-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme. Eur J Med Chem 103:56-68 (2015) [PubMed]  Article 
Target
Name:
Estradiol 17-beta-dehydrogenase 2
Synonyms:
17-beta-HSD 2 | 17-beta-hydroxysteroid dehydrogenase type 2 | DHB2_RAT | Edh17b2 | Estradiol 17-beta-dehydrogenase 2 | Hsd17b2 | Testosterone 17-beta-dehydrogenase
Type:
PROTEIN
Mol. Mass.:
41973.66
Organism:
Rattus norvegicus
Description:
ChEMBL_104364
Residue:
381
Sequence:
MNPFSSESAWLCLTATAVLGGMLLCKAWSSGQLRSQVVCLAGLWGGACLLSLSLLCSLFLLSVSCFFLLYVSSSDQDLLPVDQKAVLVTGADSGFGHALAKHLDKLGFTVFAGVLDKEGPGAEELRKNCSERLSVLQMDVTKPEQIKDVHSEVAEKIQDKGLWAVVNNAGVLHFPIDGELIPMTVYRKCMAVNFFGAVEVTKVFLPLLRKSKGRLVNVSSMGAMIPFQMVAAYASTKAAISMFSAVIRQELAKWGVKVVTIHPGGFQTNIVGSQDSWDKMEKEILDHFSKEIQENYGQEYVHTQKLALPVMREMSNPDITPVLRDIQHAICAKNPSSFYCSGRMTYLWICFAAYSPISLLDYILKNYFTPKLMPRALRTAS
  
Inhibitor
Name:
BDBM50126973
Synonyms:
CHEMBL3629587
Type:
Small organic molecule
Emp. Form.:
C24H14F5NO4S2
Mol. Mass.:
539.494
SMILES:
Oc1ccc(F)c(C(=O)c2ccc(s2)-c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2)c1F
Structure:
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