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Target
DNA gyrase subunit B
Ligand
BDBM50135115
Substrate
n/a
Meas. Tech.
ChEMBL_1542254 (CHEMBL3745476)
IC50
<8±n/a nM
Citation
 Zhang, J; Yang, Q; Romero, JA; Cross, J; Wang, B; Poutsiaka, KM; Epie, F; Bevan, D; Wu, Y; Moy, T; Daniel, A; Chamberlain, B; Carter, N; Shotwell, J; Arya, A; Kumar, V; Silverman, J; Nguyen, K; Metcalf, CA; Ryan, D; Lippa, B; Dolle, RE Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors. ACS Med Chem Lett 6:1080-5 (2015) [PubMed]  Article 
Target
Name:
DNA gyrase subunit B
Synonyms:
DNA gyrase | DNA gyrase subunit B (DNA gyraseB) | DNA gyrase subunit B (gyrB) | GYRB_STAAU | gyrB
Type:
Enzyme Subunit
Mol. Mass.:
72530.91
Organism:
Staphylococcus aureus
Description:
n/a
Residue:
644
Sequence:
MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF
  
Inhibitor
Name:
BDBM50135115
Synonyms:
CHEMBL3741066
Type:
Small organic molecule
Emp. Form.:
C18H17N5O2S
Mol. Mass.:
367.425
SMILES:
CCCOc1nccc2c(n[nH]c12)-c1cnc(s1)-c1ccc(CO)nc1
Structure:
Search PDB for entries with ligand similarity: