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Target
Protein cereblon
Ligand
BDBM50070114
Substrate
n/a
Meas. Tech.
ChEMBL_1555516 (CHEMBL3768098)
IC50
29900±n/a nM
Citation
 Boichenko, I; Deiss, S; Bär, K; Hartmann, MD; Hernandez Alvarez, B A FRET-Based Assay for the Identification and Characterization of Cereblon Ligands. J Med Chem 59:770-4 (2016) [PubMed]  Article 
Target
Name:
Protein cereblon
Synonyms:
CRBN | CRBN_HUMAN | Protein cereblon
Type:
PROTEIN
Mol. Mass.:
50537.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116917
Residue:
442
Sequence:
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL
  
Inhibitor
Name:
BDBM50070114
Synonyms:
(+/-)-thalidomide | 2-(2,6-Dioxo-piperidin-3-yl)-isoindole-1,3-dione | 2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione | CHEMBL468 | K-17 | THALIDOMIDE | Thalomid | US11059801, Compound D-62 | [(R,S)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Type:
Small organic molecule
Emp. Form.:
C13H10N2O4
Mol. Mass.:
258.2295
SMILES:
O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: