Target
Hypoxia-inducible factor 1-alpha inhibitor
Ligand
BDBM50151392
Substrate
n/a
Meas. Tech.
ChEMBL_1561035 (CHEMBL3776331)
IC50
>500000±n/a nM
Citation
 Korczynska, MLe, DDYounger, NGregori-Puigjané, ETumber, AKrojer, TVelupillai, SGileadi, CNowak, RPIwasa, EPollock, SBOrtiz Torres, IOppermann, UShoichet, BKFujimori, DG Docking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors. J Med Chem 59:1580-98 (2016) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha inhibitor
Synonyms:
FIH1 | HIF1AN | HIF1N_HUMAN | Hypoxia-inducible factor 1 (FIH) | Hypoxia-inducible factor 1-alpha inhibitor
Type:
Enzyme
Mol. Mass.:
40278.92
Organism:
Homo sapiens (Human)
Description:
Q9NWT6
Residue:
349
Sequence:
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEEPVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNREEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWGQLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQSQVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGAPTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN
  
Inhibitor
Name:
BDBM50151392
Synonyms:
CHEMBL3775262
Type:
Small organic molecule
Emp. Form.:
C19H14N2O5
Mol. Mass.:
350.3249
SMILES:
OC(=O)c1ccnc(c1)-c1cc(NC(=O)c2ccc(O)cc2)ccc1O
Structure:
Search PDB for entries with ligand similarity: