Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50159507
Substrate
n/a
Meas. Tech.
ChEBML_1569467
IC50
>10000±n/a nM
Citation
 Harris, PAKing, BWBandyopadhyay, DBerger, SBCampobasso, NCapriotti, CACox, JADare, LDong, XFinger, JNGrady, LCHoffman, SJJeong, JUKang, JKasparcova, VLakdawala, ASLehr, RMcNulty, DENagilla, ROuellette, MTPao, CSRendina, ARSchaeffer, MCSummerfield, JDSwift, BATotoritis, RDWard, PZhang, AZhang, DMarquis, RWBertin, JGough, PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem 59:2163-78 (2016) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP
Type:
PROTEIN
Mol. Mass.:
74852.62
Organism:
Mus musculus
Description:
ChEMBL_116773
Residue:
656
Sequence:
MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVLLEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVSSTTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSSSPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFAQQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYPPNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGLNSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEIDHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
  
Inhibitor
Name:
BDBM50159507
Synonyms:
CHEMBL3785703
Type:
Small organic molecule
Emp. Form.:
C21H19N3O4
Mol. Mass.:
377.3933
SMILES:
CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r|
Structure:
Search PDB for entries with ligand similarity: