Target
Receptor-interacting serine/threonine-protein kinase 1
Ligand
BDBM50159700
Substrate
n/a
Meas. Tech.
ChEMBL_1569451 (CHEMBL3789113)
IC50
35±n/a nM
Citation
 Harris, PAKing, BWBandyopadhyay, DBerger, SBCampobasso, NCapriotti, CACox, JADare, LDong, XFinger, JNGrady, LCHoffman, SJJeong, JUKang, JKasparcova, VLakdawala, ASLehr, RMcNulty, DENagilla, ROuellette, MTPao, CSRendina, ARSchaeffer, MCSummerfield, JDSwift, BATotoritis, RDWard, PZhang, AZhang, DMarquis, RWBertin, JGough, PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem 59:2163-78 (2016) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 1
Synonyms:
Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75926.99
Organism:
Homo sapiens (Human)
Description:
Q13546
Residue:
671
Sequence:
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
  
Inhibitor
Name:
BDBM50159700
Synonyms:
CHEMBL3786660
Type:
Small organic molecule
Emp. Form.:
C23H19F3N6O3
Mol. Mass.:
484.4306
SMILES:
CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3cccc(c3)C3(N=N3)C(F)(F)F)[nH]n2)C1=O |r,c:27|
Structure:
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