Target
Casein kinase II subunit alpha
Ligand
BDBM50172243
Substrate
n/a
Meas. Tech.
ChEMBL_1579153 (CHEMBL3811873)
IC50
<3.0±n/a nM
Citation
 Dowling, JEAlimzhanov, MBao, LChuaqui, CDenz, CRJenkins, ELarsen, NALyne, PDPontz, TYe, QHoldgate, GASnow, LO'Connell, NFerguson, AD Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo. ACS Med Chem Lett 7:300-5 (2016) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
CK II | CK2 | CK2- alpha | CK2A1 | CSK21_HUMAN | CSNK2A1 | Casein kinase 2 | Casein kinase II (CK2) | Casein kinase II alpha/beta | Casein kinase II subunit alpha (CK2 alpha) | Casein kinase II subunit alpha (CK2A1) | Casein kinase II subunit alpha (CK2a I174A) | Casein kinase II subunit alpha (CK2a V66A) | Casein kinase II subunit alpha (CK2a dm V66I174AA) | Casein kinase II subunit alpha (CK2a)
Type:
Enzyme
Mol. Mass.:
45151.12
Organism:
Homo sapiens (Human)
Description:
P68400
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
  
Inhibitor
Name:
BDBM50172243
Synonyms:
CHEMBL3103192
Type:
Small organic molecule
Emp. Form.:
C21H25N9O
Mol. Mass.:
419.4829
SMILES:
CN(CCN)c1ccc(Nc2cc(NC3CC3)n3ncc(C#N)c3n2)cc1NC(C)=O
Structure:
Search PDB for entries with ligand similarity: