Target
Acyl-protein thioesterase 1
Ligand
BDBM162377
Substrate
n/a
Meas. Tech.
ChEMBL_1581787 (CHEMBL3816313)
IC50
53600±n/a nM
Citation
 Wu, WLHao, JDomalski, MBurnett, DAPissarnitski, DZhao, ZStamford, AScapin, GGao, YDSoriano, AKelly, TMYao, ZPowles, MAChen, SMei, HHwa, J Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Med Chem Lett 7:498-501 (2016) [PubMed]  Article 
Target
Name:
Acyl-protein thioesterase 1
Synonyms:
Acyl-protein thioesterase 1/2 | Apt1 | LYPA1_RAT | Lypla1 | Lysosomal phospholipase A1
Type:
PROTEIN
Mol. Mass.:
24708.49
Organism:
Rattus norvegicus
Description:
ChEMBL_12731
Residue:
230
Sequence:
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSSHIKYICPHAPVMPVTLNMSMMMPSWFDIIGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKGLVNPANVTFKVYEGMMHSSCQQEMMDVKYFIDKLLPPID
  
Inhibitor
Name:
BDBM162377
Synonyms:
US9051329, Example 2
Type:
Small organic molecule
Emp. Form.:
C21H22N8O2
Mol. Mass.:
418.4518
SMILES:
CN1C(=O)Cn2c1nc1nc(N3CCC[C@@H](N)C3)n(Cc3ccccc3C#N)c1c2=O |r|
Structure:
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