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Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM50179183
Substrate
n/a
Meas. Tech.
ChEMBL_1582564 (CHEMBL3816826)
IC50
20000±n/a nM
Citation
 Kossmann, BR; Abdelmalak, M; Lopez, S; Tender, G; Yan, C; Pommier, Y; Marchand, C; Ivanov, I Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett 26:3232-3236 (2016) [PubMed]  Article 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
TRAF and TNF receptor-associated protein homolog | TYDP2_DANRE | Tyr-DNA phosphodiesterase 2 | Tyrosyl-DNA phosphodiesterase 2 | si:dkey-218n20.5 | tdp2 | ttrap | ttrap | ttrapl
Type:
PROTEIN
Mol. Mass.:
41494.89
Organism:
Danio rerio
Description:
ChEMBL_116802
Residue:
369
Sequence:
MSALGESRTRLCDQFAFVSGSDSAVAQCYLAENEWDMERALNSFFEAHMDSVFDEEAEKTEVTGNKRKDDTAEASGTKKKLKTDNADCIDLTAEEPTCSITVNSKENQAENGTAKSEVEDSKLSIISWNVDGLDTLNLADRARGLCSYLALYTPDVVFLQELIPAYVQYLKKRAVSYLFFEGSDDGYFTGIMLRKSRVKFLESEIICFPTTQMMRNLLIAQVTFSGQKLYLMTSHLESCKNQSQERTKQLRVVLQKIKEAPEDAIVIFAGDTNLRDAEVANVGGLPAGVCDVWEQLGKQEHCRYTWDTKANSNKTVPYVSRCRFDRIFLRSAKTAPPVTPDHMALIGMEKLDCGRYTSDHWGIYCTFNT
  
Inhibitor
Name:
BDBM50179183
Synonyms:
CHEMBL576840 | NSC-3198
Type:
Small organic molecule
Emp. Form.:
C22H24N2O6S2
Mol. Mass.:
476.566
SMILES:
OC(=O)C(CSSCC(NC(=O)Cc1ccccc1)C(O)=O)NC(=O)Cc1ccccc1
Structure:
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