Target
Tyrosyl-DNA phosphodiesterase 2
Ligand
BDBM50179250
Substrate
n/a
Meas. Tech.
ChEMBL_1582563 (CHEMBL3816825)
IC50
15000±n/a nM
Citation
 Kossmann, BRAbdelmalak, MLopez, STender, GYan, CPommier, YMarchand, CIvanov, I Discovery of selective inhibitors of tyrosyl-DNA phosphodiesterase 2 by targeting the enzyme DNA-binding cleft. Bioorg Med Chem Lett 26:3232-3236 (2016) [PubMed]  Article 
Target
Name:
Tyrosyl-DNA phosphodiesterase 2
Synonyms:
TYDP2_MOUSE | Tdp2 | Ttrap | Tyrosyl-DNA phosphodiesterase 2 (mTDP2 WT)
Type:
Protein
Mol. Mass.:
41027.02
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
370
Sequence:
MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFALVGGCDPTMVPSVLRENDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNEDANDTTILEASPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
  
Inhibitor
Name:
BDBM50179250
Synonyms:
CHEMBL3813826
Type:
Small organic molecule
Emp. Form.:
C23H19N5O6S
Mol. Mass.:
493.492
SMILES:
OC(=O)C1=NN(C(=O)\C1=C/c1ccc(cc1)N(CCC#N)CCC#N)c1ccc(cc1)S(O)(=O)=O |t:3|
Structure:
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