Target
N-lysine methyltransferase SMYD2
Ligand
BDBM50180955
Substrate
n/a
Meas. Tech.
ChEMBL_1585294 (CHEMBL3821557)
Ki
8±n/a nM
Citation
 Eggert, EHillig, RCKoehr, SStöckigt, DWeiske, JBarak, NMowat, JBrumby, TChrist, CDTer Laak, ALang, TFernandez-Montalvan, AEBadock, VWeinmann, HHartung, IVBarsyte-Lovejoy, DSzewczyk, MKennedy, SLi, FVedadi, MBrown, PJSanthakumar, VArrowsmith, CHStellfeld, TStresemann, C Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem 59:4578-600 (2016) [PubMed]  Article 
Target
Name:
N-lysine methyltransferase SMYD2
Synonyms:
HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN
Type:
Enzyme
Mol. Mass.:
49689.57
Organism:
Homo sapiens (Human)
Description:
Q9NRG4
Residue:
433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
  
Inhibitor
Name:
BDBM50180955
Synonyms:
CHEMBL3818617
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2F2N6O3
Mol. Mass.:
525.335
SMILES:
CCN([C@H]1CN(N=C1c1ccc(Cl)c(Cl)c1)C(\Nc1cccc(OC(F)F)c1)=N/C#N)C(=O)CO |r,c:6|
Structure:
Search PDB for entries with ligand similarity: