Reaction Details Report a problem with these data
Target
Chromobox protein homolog 7
Ligand
BDBM50189780
Substrate
n/a
Meas. Tech.
ChEMBL_1590117 (CHEMBL3829385)
Ki
33100±n/a nM
Citation
 Ren, C; Smith, SG; Yap, K; Li, S; Li, J; Mezei, M; Rodriguez, Y; Vincek, A; Aguilo, F; Walsh, MJ; Zhou, MM Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7. ACS Med Chem Lett 7:601-5 (2016) [PubMed]  Article 
Target
Name:
Chromobox protein homolog 7
Synonyms:
CBX7 | CBX7_HUMAN | Chromobox protein homolog 7 | Chromobox protein homolog 7 (CBX7)
Type:
Protein
Mol. Mass.:
28351.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
251
Sequence:
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
  
Inhibitor
Name:
BDBM50189780
Synonyms:
CHEMBL3827954
Type:
Small organic molecule
Emp. Form.:
C22H26N2O5
Mol. Mass.:
398.4522
SMILES:
COc1cccc(C(=O)N2CCN(CC2)C(=O)COc2cccc(C)c2)c1OC
Structure:
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