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Target
Excitatory amino acid transporter 3
Ligand
BDBM50093753
Substrate
n/a
Meas. Tech.
ChEMBL_1619057 (CHEMBL3861226)
IC50
3700±n/a nM
Citation
 Hansen, JC; Bjørn-Yoshimoto, WE; Bisballe, N; Nielsen, B; Jensen, AA; Bunch, L ß-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences. J Med Chem 59:8771-8786 (2016) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50093753
Synonyms:
(2S,3S)-2-Amino-3-benzyloxy-succinic acid | (2S,3S)-2-amino-3-(benzyloxy)succinic acid | (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID | CHEMBL79140 | DL-TBOA
Type:
Small organic molecule
Emp. Form.:
C11H13NO5
Mol. Mass.:
239.2246
SMILES:
N[C@@H]([C@H](OCc1ccccc1)C(O)=O)C(O)=O |r|
Structure:
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