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Target
Adenosine receptor A1
Ligand
BDBM50199620
Substrate
n/a
Meas. Tech.
ChEMBL_1621693 (CHEMBL3863976)
IC50
2.0±n/a nM
Citation
 Grŕcia, J; Buil, MA; Castro, J; Eichhorn, P; Ferrer, M; Gavaldŕ, A; Hernández, B; Segarra, V; Lehner, MD; Moreno, I; Pagčs, L; Roberts, RS; Serrat, J; Sevilla, S; Taltavull, J; Andrés, M; Cabedo, J; Vilella, D; Calama, E; Carcasona, C; Miralpeix, M Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships. J Med Chem 59:10479-10497 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50199620
Synonyms:
CHEMBL3916846
Type:
Small organic molecule
Emp. Form.:
C31H32Cl2N8O3
Mol. Mass.:
635.544
SMILES:
CCn1nc(cc(NC(=O)Nc2c(Cl)cncc2Cl)c1=O)-c1cccc(c1)-c1cccc(c1)C(=O)NCCN1CCNCC1
Structure:
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