Target
Nuclear receptor ROR-gamma
Ligand
BDBM50203508
Substrate
n/a
Meas. Tech.
ChEMBL_1625734 (CHEMBL3868203)
IC50
140±n/a nM
Citation
 Ouvry, GBouix-Peter, CCiesielski, FChantalat, LChristin, OComino, CDuvert, DFeret, CHarris, CSLamy, LLuzy, APMusicki, BOrfila, DPascau, JParnet, VPerrin, APierre, RPolge, GRaffin, CRival, YTaquet, NThoreau, EHennequin, LF Discovery of phenoxyindazoles and phenylthioindazoles as ROR¿ inverse agonists. Bioorg Med Chem Lett 26:5802-5808 (2016) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50203508
Synonyms:
CHEMBL3968165
Type:
Small organic molecule
Emp. Form.:
C20H12Cl2N2O3
Mol. Mass.:
399.227
SMILES:
OC(=O)c1ccc(cc1)-n1nc(Oc2c(Cl)cccc2Cl)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: