Reaction Details Report a problem with these data
Target
Tyrosinase
Ligand
BDBM50205807
Substrate
n/a
Meas. Tech.
ChEMBL_1628554 (CHEMBL3871139)
Ki
350±n/a nM
Citation
 Haudecoeur, R; Carotti, M; Gouron, A; Maresca, M; Buitrago, E; Hardré, R; Bergantino, E; Jamet, H; Belle, C; Réglier, M; Bubacco, L; Boumendjel, A 2-Hydroxypyridine- ACS Med Chem Lett 8:55-60 (2017) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50205807
Synonyms:
CHEMBL3978212
Type:
Small organic molecule
Emp. Form.:
C14H9NO5
Mol. Mass.:
271.225
SMILES:
Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(=O)n(O)c1
Structure:
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