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Target
BCR/ABL p210 fusion protein
Ligand
BDBM50211223
Substrate
n/a
Meas. Tech.
ChEMBL_1636131 (CHEMBL3879029)
EC50
<100±n/a nM
Citation
Wang, Q; Liu, F; Wang, B; Zou, F; Qi, Z; Chen, C; Yu, K; Hu, C; Qi, S; Wang, W; Hu, Z; Liu, J; Wang, W; Wang, L; Liang, Q; Zhang, S; Ren, T; Liu, Q; Liu, J Discovery of 4-Methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-yl)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding. J Med Chem 60:273-289 (2017) [PubMed] Article
More Info.:
Target
Name:
BCR/ABL p210 fusion protein
Synonyms:
BCR/ABL | BCR/ABL p210 fusion protein | fusion
Type:
PROTEIN
Mol. Mass.:
10728.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102433
Residue:
97
Sequence:
QMLTNSCVKLQTVHSIPLTINKEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWC