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Target
Diacylglycerol lipase-beta
Ligand
BDBM50211236
Substrate
n/a
Meas. Tech.
ChEMBL_1636262 (CHEMBL3879160)
IC50
40±n/a nM
Citation
 Deng, H; Kooijman, S; van den Nieuwendijk, AM; Ogasawara, D; van der Wel, T; van Dalen, F; Baggelaar, MP; Janssen, FJ; van den Berg, RJ; den Dulk, H; Cravatt, BF; Overkleeft, HS; Rensen, PC; van der Stelt, M Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. J Med Chem 60:428-440 (2017) [PubMed]  Article 
Target
Name:
Diacylglycerol lipase-beta
Synonyms:
DGL-beta | DGLB_MOUSE | Daglb | Sn1-specific diacylglycerol lipase beta
Type:
PROTEIN
Mol. Mass.:
73906.34
Organism:
Mus musculus
Description:
ChEMBL_101275
Residue:
669
Sequence:
MPGMVLFGRRWSLASDDLVFPGSFELFLRVLWWIVSLTLYLTHRRRLDCPGGVLLSTYLIVLLVLLAVIICTVLAIVCVSMRGTICNPGPRKSMSKLLYIRLALFLPEMVWASLGAAWVAKGIQCDRTVVIGIIATVIVSWIVIAATMVTIIFVFDPLGGKMAPYPPCIPEHLDSNSSNRLLTGLKTAAKSVWETRVQFCCCCVGQDDNTRVAFSSTADLFSTYFSDTDLVPSDIAAGFTLLHQQQDNISHSREPPEVVTHTPGQPQETELDAEVENCHHYMPFAAAAYGWPLYIYRNPFTGLCRIGGDCCRARDIEYDAVEGDQHNCHFASILKTTGLQYRDFIHISFHDKVYELPFIVVLDHRKESVVVAVRGTMSLQDVLTDLSAESETLELGIELQDCVAHKGIAQAARYIHRRLVNDGILSQAFSVAPEYQLVLVGHSLGAGAAALLAIMLRGAYPQVRAYAFSPPRGLLSKSLYEYSKDFVVSLILGMDVIPRLSVTNMEDLKRRILRVIANCNKPKYKILLHGCWYGLFGGSPDNFPTELDEGTQGALTQPLLGEQTLLTRYSPGYCSSDSPLDSPTKYPTLYPPGRIIHLEEEGGSGRFGCCSAAQYRARWAHEAEFSKILIGPKMLIDHMPDVMIRALDRVLADRTACVSCPGQGGSSVP
  
Inhibitor
Name:
BDBM50211236
Synonyms:
CHEMBL2144065
Type:
Small organic molecule
Emp. Form.:
C27H26N4O
Mol. Mass.:
422.5215
SMILES:
O=C(N1CCCCC1Cc1ccccc1)n1cc(nn1)-c1ccc(cc1)-c1ccccc1
Structure:
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