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Target
Methionine aminopeptidase 2
Ligand
BDBM76305
Substrate
n/a
Meas. Tech.
ChEMBL_1636404 (CHEMBL3879302)
IC50
55±n/a nM
Citation
 Helgren, TR; Chen, C; Wangtrakuldee, P; Edwards, TE; Staker, BL; Abendroth, J; Sankaran, B; Housley, NA; Myler, PJ; Audia, JP; Horn, JR; Hagen, TJ Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents. Bioorg Med Chem 25:813-824 (2017) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM76305
Synonyms:
5-chloranylquinolin-8-ol | 5-chloro-8-quinolinol | 5-chloroquinolin-8-ol | MLS002695956 | SMR000274338 | cid_2817
Type:
Small organic molecule
Emp. Form.:
C9H6ClNO
Mol. Mass.:
179.603
SMILES:
Oc1ccc(Cl)c2cccnc12
Structure:
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