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Target
Sporulation kinase A
Ligand
BDBM50215967
Substrate
n/a
Meas. Tech.
ChEMBL_87376 (CHEMBL694305)
IC50
4800±n/a nM
Citation
 Hlasta, DJ; Demers, JP; Foleno, BD; Fraga-Spano, SA; Guan, J; Hilliard, JJ; Macielag, MJ; Ohemeng, KA; Sheppard, CM; Sui, Z; Webb, GC; Weidner-Wells, MA; Werblood, H; Barrett, JF Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel. Bioorg Med Chem Lett 8:1923-8 (1998) [PubMed]  Article 
Target
Name:
Sporulation kinase A
Synonyms:
KINA_BACSU | Sporulation kinase A | Stage II sporulation protein F | Stage II sporulation protein J | gsiC | kinA | scoD | spoIIF | spoIIJ
Type:
PROTEIN
Mol. Mass.:
69161.05
Organism:
Bacillus subtilis (strain 168)
Description:
ChEMBL_105028
Residue:
606
Sequence:
MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGEMIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAERTEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISVKGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQTWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNSIDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQKTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEKLSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELLMLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQVFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKEKGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK
  
Inhibitor
Name:
BDBM50215967
Synonyms:
CHEMBL56579
Type:
Small organic molecule
Emp. Form.:
C22H14Cl4N2O2
Mol. Mass.:
480.171
SMILES:
Cc1cc(NC(=O)c2cc(Cl)cc(Cl)c2O)c(Cl)cc1C(C#N)c1ccc(Cl)cc1
Structure:
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