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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50221806
Substrate
n/a
Meas. Tech.
ChEMBL_155708 (CHEMBL760586)
Ki
70000±n/a nM
Comments
0.000070 20220122
Citation
 Temple, DL; Yevich, JP; Catt, JD; Owens, D; Hanning, C; Covington, RR; Seidehamel, RJ; Dungan, KW Substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones. J Med Chem 23:1188-98 (1980) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50221806
Synonyms:
CHEMBL18267
Type:
Small organic molecule
Emp. Form.:
C14H12ClN5O
Mol. Mass.:
301.731
SMILES:
Clc1ccc(CN2C3=NCCN3C(=O)c3[nH]cnc23)cc1 |t:7|
Structure:
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