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Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Ligand
BDBM50232006
Substrate
n/a
Meas. Tech.
ChEMBL_1645845 (CHEMBL3994901)
IC50
>100000±n/a nM
Citation
 Wang, K; Bao, L; Ma, K; Zhang, J; Chen, B; Han, J; Ren, J; Luo, H; Liu, H A novel class ofa-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-A Eur J Med Chem 127:1035-1046 (2017) [PubMed]  Article 
Target
Name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms:
3-hydroxy-3-methylglutaryl-coenzyme A reductase | HMDH_PIG | HMG-CoA reductase | HMGCR | HMGR
Type:
PROTEIN
Mol. Mass.:
97149.70
Organism:
Sus scrofa
Description:
ChEMBL_109835
Residue:
885
Sequence:
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNDKICGWNYECPKFEEDVLSSDIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTGLNEALPFFLLLIDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIGVGTMSGVRQLEIMCCFGCMSVLATYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFARVLEGEENKPNPVTQRVKIIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQVITLTLALLLAVKYIFFEQAETESTLSLKNPITSPVVTQKKVTDDCCRREPTLVRNDQKFHTVEEEARINRERKVEVIKPLVAETDTSSRPTFVVGNSTLDSSLELEMQEPEIQIPSEPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRILADGMTPVVRFPRACDSAEVKAWLETPEGFAVIKEAFDSTSRFARLQKLQMSVAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAVNWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMVEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIGTVGGGTSLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA
  
Inhibitor
Name:
BDBM50232006
Synonyms:
CHEMBL4079168
Type:
Small organic molecule
Emp. Form.:
C21H24O5
Mol. Mass.:
356.4123
SMILES:
C\C(CC\C=C(/C)C=O)=C/CCC1=C[C@@H](OC1=O)c1cc(O)ccc1O |r,t:12|
Structure:
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