Reaction Details Report a problem with these data
Target
DNA-directed RNA polymerase, mitochondrial
Ligand
BDBM50236025
Substrate
n/a
Meas. Tech.
ChEMBL_1658646 (CHEMBL4008258)
IC50
>200000±n/a nM
Citation
 Siegel, D; Hui, HC; Doerffler, E; Clarke, MO; Chun, K; Zhang, L; Neville, S; Carra, E; Lew, W; Ross, B; Wang, Q; Wolfe, L; Jordan, R; Soloveva, V; Knox, J; Perry, J; Perron, M; Stray, KM; Barauskas, O; Feng, JY; Xu, Y; Lee, G; Rheingold, AL; Ray, AS; Bannister, R; Strickley, R; Swaminathan, S; Lee, WA; Bavari, S; Cihlar, T; Lo, MK; Warren, TK; Mackman, RL Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem 60:1648-1661 (2017) [PubMed]  Article 
Target
Name:
DNA-directed RNA polymerase, mitochondrial
Synonyms:
2.7.7.6 | DNA-directed RNA polymerase, mitochondrial | MtRPOL | POLRMT | RPOM_HUMAN
Type:
PROTEIN
Mol. Mass.:
138671.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108039
Residue:
1230
Sequence:
MSALCWGRGAAGLKRALRPCGRPGLPGKEGTAGGVCGPRRSSSASPQEQDQDRRKDWGHVELLEVLQARVRQLQAESVSEVVVNRVDVARLPECGSGDGSLQPPRKVQMGAKDATPVPCGRWAKILEKDKRTQQMRMQRLKAKLQMPFQSGEFKALTRRLQVEPRLLSKQMAGCLEDCTRQAPESPWEEQLARLLQEAPGKLSLDVEQAPSGQHSQAQLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAVMLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIERCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPPVNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSVEKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSLYPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQRVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEELGAPEALREQPWPLPVQMELGKLLAEMLVQATQMPCSLDKPHRSSRLVPVLYHVYSFRNVQQIGILKPHPAYVQLLEKAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQELLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVPAPPSEAPQPPEAHLPHSAAPARKAELRRELAHCQKVAREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEEVMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVFRRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGSVVEWVTPLGVPVIQPYRLDSKVKQIGGGIQSITYTHNGDISRKPNTRKQKNGFPPNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVKRFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS
  
Inhibitor
Name:
BDBM50236025
Synonyms:
CHEMBL2016761 | US11149049, No. C2
Type:
Small organic molecule
Emp. Form.:
C12H16N5O13P3
Mol. Mass.:
531.2024
SMILES:
Nc1ncnn2c(ccc12)[C@@]1(O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C#N |r|
Structure:
Search PDB for entries with ligand similarity: