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Target
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Ligand
BDBM50236118
Substrate
n/a
Meas. Tech.
ChEMBL_1658774 (CHEMBL4008386)
IC50
>100000±n/a nM
Citation
 Llona-Minguez, S; Höglund, A; Wiita, E; Almlöf, I; Mateus, A; Calderón-Montaño, JM; Cazares-Körner, C; Homan, E; Loseva, O; Baranczewski, P; Jemth, AS; Häggblad, M; Martens, U; Lundgren, B; Artursson, P; Lundbäck, T; Jenmalm Jensen, A; Warpman Berglund, U; Scobie, M; Helleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem 60:2148-2154 (2017) [PubMed]  Article 
Target
Name:
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Synonyms:
3.6.1.17 | AP4A_HUMAN | APAH1 | Ap4A hydrolase | Ap4Aase | Diadenosine tetraphosphatase | NUDT2 | Nucleoside diphosphate-linked moiety X motif 2 | Nudix motif 2
Type:
PROTEIN
Mol. Mass.:
16824.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117468
Residue:
147
Sequence:
MALRACGLIIFRRCLIPKVDNNAIEFLLLQASDGIHHWTPPKGHVEPGEDDLETALRETQEEAGIEAGQLTIIEGFKRELNYVARNKPKTVIYWLAEVKDYDVEIRLSHEHQAYRWLGLEEACQLAQFKEMKAALQEGHQFLCSIEA
  
Inhibitor
Name:
BDBM50236118
Synonyms:
CHEMBL4065181
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2S2
Mol. Mass.:
344.411
SMILES:
COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1cccs1
Structure:
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