Target
Potassium voltage-gated channel subfamily A member 1
Ligand
BDBM50131434
Substrate
n/a
Meas. Tech.
ChEMBL_1659962 (CHEMBL4009574)
IC50
209000±n/a nM
Citation
 Al-Sabi, ADaly, DHoefer, PKinsella, GKMetais, CPickering, MHerron, CKaza, SKNolan, KDolly, JO A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction. J Med Chem 60:2245-2256 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 1
Synonyms:
KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56451.30
Organism:
Homo sapiens (Human)
Description:
Potassium (voltage dependent) 0 0::Q09470
Residue:
495
Sequence:
MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV
  
Inhibitor
Name:
BDBM50131434
Synonyms:
CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide | N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide | N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide (Flecainide) | N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide(Flecainide) | N-Piperidin-2-ylmethyl-2,5-bis-(2,2,2-trifluoro-ethoxy)-benzamide(Flecanide) | Tambocor
Type:
Small organic molecule
Emp. Form.:
C17H20F6N2O3
Mol. Mass.:
414.3427
SMILES:
FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
Structure:
Search PDB for entries with ligand similarity: