Reaction Details
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Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM275064
Substrate
n/a
Meas. Tech.
TNAP Inhibition Activity
Temperature
298.15±n/a K
IC50
6.10±n/a nM
Comments
extracted
Citation
Miyazaki, S; Yamamoto, Y; Suzuki, K; Inui, M; Izumi, M; Soma, K; Pinkerton, A; Shinozaki, T Pyridine compounds US Patent US9879032 Publication Date 1/30/2018 More Info.:
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Inhibitor
Name:
BDBM275064
Synonyms:
US10221195, Example 6 | US9879032, Example 6
Type:
Small organic molecule
Emp. Form.:
C17H18ClN3O6S
Mol. Mass.:
427.859
SMILES:
COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCN(CCO)C(=O)c2c1
Structure:
