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Target
Neuronal acetylcholine receptor subunit alpha-3
Ligand
BDBM50061565
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_1187
Citation
 Xiao, Y; Meyer, EL; Thompson, JM; Surin, A; Wroblewski, J; Kellar, KJ Rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor stably expressed in a transfected cell line: pharmacology of ligand binding and function. Mol Pharmacol 54:322-33 (1998) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-3
Synonyms:
ACHA3_RAT | Acra3 | Chrna3
Type:
Enzyme
Mol. Mass.:
56995.52
Organism:
Rattus norvegicus (Rat)
Description:
P04757
Residue:
499
Sequence:
MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT
  
Inhibitor
Name:
BDBM50061565
Synonyms:
(+)Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine | (+/-)Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine | (-)Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine | CHEMBL267936 | MECAMYLAMINE | Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine | Methyl-(2,3,3-trimethyl-bicyclo[2.2.1]hept-2-yl)-amine(Mecamylamine)
Type:
Small organic molecule
Emp. Form.:
C11H21N
Mol. Mass.:
167.2911
SMILES:
CNC1(C)C2CCC(C2)C1(C)C |TLB:3:2:8:5.6,THB:1:2:8:5.6|
Structure:
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