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Target
Alpha-2B adrenergic receptor
Ligand
BDBM82071
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_1947
Citation
 Bymaster, FP; Dreshfield-Ahmad, LJ; Threlkeld, PG; Shaw, JL; Thompson, L; Nelson, DL; Hemrick-Luecke, SK; Wong, DT Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 25:871-80 (2001) [PubMed]  Article 
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_MOUSE | Adra2b | Alpha-2 adrenergic receptor | Alpha-2B adrenergic receptor | adrenergic Alpha2B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50186.21
Organism:
MOUSE
Description:
adrenergic Alpha2B ADRA2B MOUSE::P30545
Residue:
450
Sequence:
MVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPRPGPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTGW
  
Inhibitor
Name:
BDBM82071
Synonyms:
CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENLAFAXINE | Venlafaxine hydrochloride | WY-45030 | WY-45655
Type:
Small organic molecule
Emp. Form.:
C17H27NO2
Mol. Mass.:
277.4018
SMILES:
COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1
Structure:
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