Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Ligand
BDBM50010981
Substrate
n/a
Ki
>10000±n/a nM
Comments
PDSP_3034
Citation
 Zhao, YZhang, HTO'Donnell, JM Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. J Pharmacol Exp Ther 305:565-72 (2003) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:
DPDE4 | PDE4B_RAT | Pde4b | Phosphodiesterase 4B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
83349.50
Organism:
RAT
Description:
P14646
Residue:
736
Sequence:
MKKSRSVMAVTADDNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSSGLVLHAAFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRIVRNNFTLLTNLHGAPNKRSPAASQAPVTRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLMEKFQFELTLEEEDSEGPEKEGEGPNYFSSTKTLCVIDPENRDSLEETDIDIATEDKSLIDT
  
Inhibitor
Name:
BDBM50010981
Synonyms:
(Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one | 4-(3-Butoxy-4-methoxy-benzyl)-imidazolidin-2-one(Ro 20-1724) | 4-(3-Butyl-4-methoxy-benzyl)-imidazolidin-2-one | CHEMBL18701 | RO 20-1724 | Ro-20-1724
Type:
Small organic molecule
Emp. Form.:
C15H22N2O3
Mol. Mass.:
278.3468
SMILES:
CCCCOc1cc(CC2CNC(=O)N2)ccc1OC
Structure:
Search PDB for entries with ligand similarity: