Reaction Details
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Calcium-activated potassium channel subunit beta
Ligand
BDBM86244
Substrate
n/a
Ki
4.9±n/a nM
Comments
PDSP_3710
Citation
Davis-Taber, R; Molinari, EJ; Altenbach, RJ; Whiteaker, KL; Shieh, CC; Rotert, G; Buckner, SA; Malysz, J; Milicic, I; McDermott, JS; Gintant, GA; Coghlan, MJ; Carroll, WA; Scott, VE; Gopalakrishnan, M [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding. Mol Pharmacol 64:143-53 (2003) [PubMed] Article More Info.:
Target
Name:
Calcium-activated potassium channel subunit beta
Synonyms:
Potassium channel (ATP modulatory)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22836.62
Organism:
GUINEA PIG
Description:
C0KY85
Residue:
199
Sequence:
GSHAKPFMLSTQREESNCTIIHTHIMDDWMDCAFTCGVDCQGQGKYPCLQVFVNLTHSGQKALLHYNEEAVQINSKCFYTPKCRRDGNDLLNSALNIKEFFDHKNRTPFSCFYSPDNQSEDVILIKKYDQMVIFHCLFWPSMTMLGGALIVGMVRLTQYLFLLCEKYSTALRDEVSGKVPYVARNQFKLWSVGRSKGRA
Inhibitor
Name:
BDBM86244
Synonyms:
A-312110
Type:
Small organic molecule
Emp. Form.:
C16H13FINO4S
Mol. Mass.:
461.247
SMILES:
Fc1ccc(cc1I)[C@@H]1C2C(=O)COCC2=NC2=C1S(=O)(=O)CC2 |r,c:17,19|
Structure:
