Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50117181
Substrate
n/a
Ki
38±n/a nM
Comments
PDSP_4942
Citation
Sit, SY; Xie, K; Jacutin-Porte, S; Boy, KM; Seanz, J; Taber, MT; Gulwadi, AG; Korpinen, CD; Burris, KD; Molski, TF; Ryan, E; Xu, C; Verdoorn, T; Johnson, G; Nichols, DE; Mailman, RB Synthesis and SAR exploration of dinapsoline analogues. Bioorg Med Chem 12:715-34 (2004) [PubMed] Article
More Info.:
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Inhibitor
Name:
BDBM50117181
Synonyms:
(S)-2,3,7,11b-Tetrahydro-1H-dibenzo[de,h]isoquinoline-8,9-diol | 2,3,7,11b-Tetrahydro-1H-dibenzo[de,h]isoquinoline-8,9-diol | CHEMBL124561 | Dinapsoline, (+/-) | Dinapsoline, (R)(+)
Type:
Small organic molecule
Emp. Form.:
C16H15NO2
Mol. Mass.:
253.2958
SMILES:
Oc1ccc2[C@@H]3CNCc4cccc(Cc2c1O)c34