Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM49141
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
35000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3G DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM49141
Synonyms:
6-bromo-N-piperonyl-pyrazolo[1,5-a]pyrimidine-2-carboxamide | MLS000052865 | N-(1,3-benzodioxol-5-ylmethyl)-6-bromanyl-pyrazolo[1,5-a]pyrimidine-2-carboxamide | N-(1,3-benzodioxol-5-ylmethyl)-6-bromo-2-pyrazolo[1,5-a]pyrimidinecarboxamide | N-(1,3-benzodioxol-5-ylmethyl)-6-bromopyrazolo[1,5-a]pyrimidine-2-carboxamide | SMR000082680 | cid_2240578
Type:
Small organic molecule
Emp. Form.:
C15H11BrN4O3
Mol. Mass.:
375.177
SMILES:
Brc1cnc2cc(nn2c1)C(=O)NCc1ccc2OCOc2c1
Structure:
