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Target
Phospholipase D2
Ligand
BDBM87219
Substrate
n/a
Meas. Tech.
Cellular PLD2 concentration response
IC50
730±n/a nM
Citation
 PubChem, PC Cellular PLD2 concentration response PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase D2
Synonyms:
PLD2 | PLD2_HUMAN | Phospholipase D2 | Phospholipase D2 (PLD2) | phospholipase D2 isoform PLD2A
Type:
Protein
Mol. Mass.:
106002.47
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
933
Sequence:
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT
  
Inhibitor
Name:
BDBM87219
Synonyms:
N-[(1S)-2-[4-(5-chloro-2-keto-3H-benzimidazol-1-yl)piperidino]-1-methyl-ethyl]-3,4-difluoro-benzamide;2,2,2-trifluoroacetic acid | N-[(2S)-1-[4-(5-chloranyl-2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-3,4-bis(fluoranyl)benzamide;2,2,2-tris(fluoranyl)ethanoic acid | N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]propan-2-yl]-3,4-difluorobenzamide;2,2,2-trifluoroacetic acid | N-[(2S)-1-[4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl]-3,4-difluorobenzamide;2,2,2-trifluoroacetic acid | VU0359560-1 | cid_53470198
Type:
Small organic molecule
Emp. Form.:
C22H23ClF2N4O2
Mol. Mass.:
448.893
SMILES:
C[C@@H](CN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)NC(=O)c1ccc(F)c(F)c1
Structure:
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