Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87267
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
10783±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87267
Synonyms:
4-[2-(4-Chloro-phenoxy)-acetylamino]-N-pyridin-3-ylmethyl-benzamide | 4-[2-(4-chloranylphenoxy)ethanoylamino]-N-(pyridin-3-ylmethyl)benzamide | 4-[[2-(4-chlorophenoxy)-1-oxoethyl]amino]-N-(3-pyridinylmethyl)benzamide | 4-[[2-(4-chlorophenoxy)acetyl]amino]-N-(3-pyridylmethyl)benzamide | 4-[[2-(4-chlorophenoxy)acetyl]amino]-N-(pyridin-3-ylmethyl)benzamide | MLS000557102 | SMR000172649 | cid_1150809
Type:
Small organic molecule
Emp. Form.:
C21H18ClN3O3
Mol. Mass.:
395.839
SMILES:
Clc1ccc(OCC(=O)Nc2ccc(cc2)C(=O)NCc2cccnc2)cc1
Structure:
Search PDB for entries with ligand similarity: