Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87296
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
13100±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87296
Synonyms:
2-(3-nitroanilino)-N-[(E)-(5-nitro-2-furanyl)methylideneamino]acetamide | 2-(3-nitroanilino)-N-[(E)-(5-nitro-2-furyl)methyleneamino]acetamide | 2-(3-nitroanilino)-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]acetamide | 2-{3-nitroanilino}-N'-({5-nitro-2-furyl}methylene)acetohydrazide | MLS000702290 | N-[(E)-(5-nitrofuran-2-yl)methylideneamino]-2-[(3-nitrophenyl)amino]ethanamide | SMR000224514 | cid_6872741
Type:
Small organic molecule
Emp. Form.:
C13H11N5O6
Mol. Mass.:
333.2563
SMILES:
[O-][N+](=O)c1ccc(\C=N\NC(=O)CNc2cccc(c2)[N+]([O-])=O)o1
Structure:
Search PDB for entries with ligand similarity: