Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87305
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
10577±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87305
Synonyms:
MLS000660882 | N'-[(1E)-(4,5-dibromothien-2-yl)methylene]isonicotinohydrazide | N-[(E)-(4,5-dibromo-2-thienyl)methyleneamino]isonicotinamide | N-[(E)-(4,5-dibromo-2-thiophenyl)methylideneamino]-4-pyridinecarboxamide | N-[(E)-(4,5-dibromothiophen-2-yl)methylideneamino]pyridine-4-carboxamide | N-[(E)-[4,5-bis(bromanyl)thiophen-2-yl]methylideneamino]pyridine-4-carboxamide | SMR000310520 | cid_9682721
Type:
Small organic molecule
Emp. Form.:
C11H7Br2N3OS
Mol. Mass.:
389.066
SMILES:
Brc1cc(\C=N\NC(=O)c2ccncc2)sc1Br
Structure:
Search PDB for entries with ligand similarity: