Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM87328
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
15214±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM87328
Synonyms:
1-[(E)-(6-chloranyl-2,3-dihydrothiochromen-4-ylidene)amino]thiourea | 2-(6-chloro-3,4-dihydro-2H-1-benzothiin-4-yliden)hydrazine-1-carbothioamide | MLS000861999 | SMR000461081 | [(E)-(6-chloro-2,3-dihydro-1-benzothiopyran-4-ylidene)amino]thiourea | [(E)-(6-chloro-2,3-dihydrothiochromen-4-ylidene)amino]thiourea | [(E)-(6-chlorothiochroman-4-ylidene)amino]thiourea | cid_9580662
Type:
Small organic molecule
Emp. Form.:
C10H10ClN3S2
Mol. Mass.:
271.79
SMILES:
NC(=S)NN=C1CCSc2ccc(Cl)cc12 |w:4.3|
Structure:
Search PDB for entries with ligand similarity: