Reaction Details Report a problem with these data
Target
High affinity choline transporter 1
Ligand
BDBM87574
Substrate
n/a
Meas. Tech.
JHICC_CHT_Inh_3H uptake_CRC
IC50
15954.08477±n/a nM
Citation
 PubChem, PC JHICC_CHT_Inh_3H uptake_CRC PubChem Bioassay (2012)[AID] 
Target
Name:
High affinity choline transporter 1
Synonyms:
CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1
Type:
PROTEIN
Mol. Mass.:
63194.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1464247
Residue:
580
Sequence:
MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGGLYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSWLDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDWNQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQLLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFKTLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLDELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
  
Inhibitor
Name:
BDBM87574
Synonyms:
MLS001082585 | N-[2-(1-cyclohexenyl)ethyl]-4-methoxy-3-[(1-propan-2-yl-4-piperidinyl)oxy]benzamide | N-[2-(cyclohexen-1-yl)ethyl]-3-[(1-isopropyl-4-piperidyl)oxy]-4-methoxy-benzamide | N-[2-(cyclohexen-1-yl)ethyl]-4-methoxy-3-(1-propan-2-ylpiperidin-4-yl)oxy-benzamide | N-[2-(cyclohexen-1-yl)ethyl]-4-methoxy-3-(1-propan-2-ylpiperidin-4-yl)oxybenzamide | SMR000655389 | cid_24793028
Type:
Small organic molecule
Emp. Form.:
C24H36N2O3
Mol. Mass.:
400.5542
SMILES:
COc1ccc(cc1OC1CCN(CC1)C(C)C)C(=O)NCCC1=CCCCC1 |t:25|
Structure:
Search PDB for entries with ligand similarity: