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Target
Polyadenylate-binding protein 1
Ligand
BDBM87590
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87590
Synonyms:
MLS000073393 | N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-ethyl-methanesulfonamide | N-(1,5-dimethyl-3-oxidanylidene-2-phenyl-pyrazol-4-yl)-N-ethyl-methanesulfonamide | N-(1,5-dimethyl-3-oxo-2-phenyl-4-pyrazolyl)-N-ethylmethanesulfonamide | N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-N-ethylmethanesulfonamide | N-ethyl-N-(3-keto-1,5-dimethyl-2-phenyl-3-pyrazolin-4-yl)methanesulfonamide | SMR000013826 | cid_645207
Type:
Small organic molecule
Emp. Form.:
C14H19N3O3S
Mol. Mass.:
309.384
SMILES:
CCN(c1c(C)n(C)n(-c2ccccc2)c1=O)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: