Reaction Details Report a problem with these data
Target
Polyadenylate-binding protein 1
Ligand
BDBM87655
Substrate
n/a
Meas. Tech.
Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay
IC50
>66000±n/a nM
Citation
 PubChem, PC Dose-response confirmation of microRNA-mediated mRNA deadenylation inhibitors by fluoresence polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
Polyadenylate-binding protein 1
Synonyms:
PAB1 | PABP | PABP1 | PABP1_HUMAN | PABPC1 | PABPC2 | poly(A) binding protein, cytoplasmic 1 | polyadenylate-binding protein 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
70694.26
Organism:
Homo sapiens (Human)
Description:
gi_46367787
Residue:
636
Sequence:
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
  
Inhibitor
Name:
BDBM87655
Synonyms:
2-({[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methyl}thio)-N-(tetrahydrofuran-2-ylmethyl)acetamide | 2-[[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfanyl]-N-(oxolan-2-ylmethyl)acetamide | 2-[[2-(3-methoxyphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfanyl]-N-(oxolan-2-ylmethyl)ethanamide | 2-[[2-(3-methoxyphenyl)-5-methyl-4-oxazolyl]methylthio]-N-(2-oxolanylmethyl)acetamide | 2-[[2-(3-methoxyphenyl)-5-methyl-oxazol-4-yl]methylthio]-N-(tetrahydrofurfuryl)acetamide | MLS000089356 | SMR000027731 | cid_3236486
Type:
Small organic molecule
Emp. Form.:
C19H24N2O4S
Mol. Mass.:
376.47
SMILES:
COc1cccc(c1)-c1nc(CSCC(=O)NCC2CCCO2)c(C)o1
Structure:
Search PDB for entries with ligand similarity: