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Target
Delta-type opioid receptor
Ligand
BDBM88432
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>64588±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88432
Synonyms:
(E)-1-[1-[2-(4-methylphenyl)-2-oxidanylidene-ethyl]benzimidazol-2-yl]-3-phenyl-prop-2-en-1-one | (E)-1-[1-[2-(4-methylphenyl)-2-oxoethyl]-2-benzimidazolyl]-3-phenyl-2-propen-1-one | (E)-1-[1-[2-(4-methylphenyl)-2-oxoethyl]benzimidazol-2-yl]-3-phenylprop-2-en-1-one | (E)-1-[1-[2-keto-2-(p-tolyl)ethyl]benzimidazol-2-yl]-3-phenyl-prop-2-en-1-one | 1-{1-[2-(4-methylphenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-3-phenyl-2-propen-1-one | MLS000545812 | SMR000163983 | cid_6260079
Type:
Small organic molecule
Emp. Form.:
C25H20N2O2
Mol. Mass.:
380.4385
SMILES:
Cc1ccc(cc1)C(=O)Cn1c(nc2ccccc12)C(=O)C=Cc1ccccc1 |w:21.23|
Structure:
Search PDB for entries with ligand similarity: