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Target
Delta-type opioid receptor
Ligand
BDBM88477
Substrate
n/a
Meas. Tech.
Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R)
EC50
>92389±n/a nM
Citation
 PubChem, PC Counterscreen for biased ligands (agonists) of the melanocortin 4 receptor (MC4R): Luminescence-based cell-based high throughput dose response assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors PubChem Bioassay (2012)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM88477
Synonyms:
2-(4-{[3-(trifluoromethyl)-2-pyridyl]oxy}phenyl)-4,5-dihydro-1,3-thiazole | 2-[4-[3-(trifluoromethyl)pyridin-2-yl]oxyphenyl]-4,5-dihydro-1,3-thiazole | 2-[4-[[3-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-4,5-dihydrothiazole | 2-[4-[[3-(trifluoromethyl)-2-pyridyl]oxy]phenyl]-2-thiazoline | MLS000834881 | SMR000461397 | cid_2744571
Type:
Small organic molecule
Emp. Form.:
C15H11F3N2OS
Mol. Mass.:
324.321
SMILES:
FC(F)(F)c1cccnc1Oc1ccc(cc1)C1=NCCS1 |t:19|
Structure:
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