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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM83218
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
1770±224 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM83218
Synonyms:
1-[(Z)-3-indolylidenemethyl]-2-(4-nitrophenyl)hydrazine | 1-[(Z)-indol-3-ylidenemethyl]-2-(4-nitrophenyl)diazane | 1-[(Z)-indol-3-ylidenemethyl]-2-(4-nitrophenyl)hydrazine | 1H-indole-3-carbaldehyde (4-nitrophenyl)hydrazone | MLS000573812 | SMR000184664 | cid_5718086
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2
Mol. Mass.:
280.2814
SMILES:
[O-][N+](=O)c1ccc(cc1)N=[NH+]Cc1c[n-]c2ccccc12 |w:10.11|
Structure:
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