Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM61221
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
8540±618 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM61221
Synonyms:
4-[(3,4-dichlorobenzylidene)amino]-3-(3-phenyl-1H-pyrazol-5-yl)-1H-1,2,4-triazole-5-thione | 4-[(3,4-dichlorophenyl)methylideneamino]-3-(3-phenyl-1H-pyrazol-5-yl)-1H-1,2,4-triazole-5-thione | 4-[(E)-(3,4-dichlorobenzylidene)amino]-3-(3-phenyl-1H-pyrazol-5-yl)-1H-1,2,4-triazole-5-thione | 4-{[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-amino}-5-(5-phenyl-2H-pyrazol-3-yl)-4H-[1,2,4]triazole-3-t hiol | MLS000762662 | SMR000438124 | cid_1398789
Type:
Small organic molecule
Emp. Form.:
C18H12Cl2N6S
Mol. Mass.:
415.299
SMILES:
Clc1ccc(C=Nn2c(n[nH]c2=S)-c2cc([nH]n2)-c2ccccc2)cc1Cl |w:6.6|
Structure:
Search PDB for entries with ligand similarity: