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Target
26S proteasome non-ATPase regulatory subunit 14
Ligand
BDBM79219
Substrate
n/a
Meas. Tech.
Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay
IC50
6850±434 nM
Citation
 PubChem, PC Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay PubChem Bioassay (2012)[AID] 
Target
Name:
26S proteasome non-ATPase regulatory subunit 14
Synonyms:
26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein
Type:
Protein
Mol. Mass.:
34576.68
Organism:
Homo sapiens (Human)
Description:
O00487
Residue:
310
Sequence:
MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKHNESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCLAAMLDTVVFK
  
Inhibitor
Name:
BDBM79219
Synonyms:
6-cyclopropyl-1-isopropyl-N-(4-sulfamoylphenyl)pyrazolo[3,4-b]pyridine-4-carboxamide | 6-cyclopropyl-1-propan-2-yl-N-(4-sulfamoylphenyl)-4-pyrazolo[3,4-b]pyridinecarboxamide | 6-cyclopropyl-1-propan-2-yl-N-(4-sulfamoylphenyl)pyrazolo[3,4-b]pyridine-4-carboxamide | MLS002171224 | SMR001251521 | cid_9268118
Type:
Small organic molecule
Emp. Form.:
C19H21N5O3S
Mol. Mass.:
399.467
SMILES:
CC(C)n1ncc2c(cc(nc12)C1CC1)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Structure:
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